GDF11 Controls the Timing of Progenitor Cell Competence in Developing Retina

@article{Kim2005GDF11CT,
  title={GDF11 Controls the Timing of Progenitor Cell Competence in Developing Retina},
  author={Joon Ha Kim and Hsiao-Huei Wu and Arthur D. Lander and Karen M. Lyons and Martin M. Matzuk and Anne L. Calof},
  journal={Science},
  year={2005},
  volume={308},
  pages={1927 - 1930}
}
The orderly generation of cell types in the developing retina is thought to be regulated by changes in the competence of multipotent progenitors. Here, we show that a secreted factor, growth and differentiation factor 11 (GDF11), controls the numbers of retinal ganglion cells (RGCs), as well as amacrine and photoreceptor cells, that form during development. GDF11 does not affect proliferation of progenitors—a major mode of GDF11 action in other tissues—but instead controls duration of… 
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