GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding.

@article{Thies2001GDF8PB,
  title={GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding.},
  author={Robert Scott Thies and Tsuhan Chen and Monique V. Davies and Kathleen N. Tomkinson and Adele A Pearson and Quazi Aga Shakey and Neil M. Wolfman},
  journal={Growth factors},
  year={2001},
  volume={18 4},
  pages={
          251-9
        }
}
GDF-8 is a new member of the TGF-beta superfamily which appears to be a negative regulator of skeletal muscle mass. Factors which regulate the biological activity of GDF-8 have not yet been identified. However, the biological activities of TGF-beta superfamily members, TGF-beta1, -beta2 and -beta3, can be inhibited by noncovalent association with TGF-beta1, -beta2 and beta3 propeptides cleaved from the amino-termini of the TGF-beta precursor proteins. In contrast, the propeptides of other TGF… CONTINUE READING
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