GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.

@article{Artz2016GDF15II,
  title={GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer.},
  author={Annette Artz and Stefan Butz and Dietmar Vestweber},
  journal={Blood},
  year={2016},
  volume={128 4},
  pages={529-41}
}
Growth differentiation factor 15 (GDF-15) is the first cytokine known to counteract chemokine-induced activation of leukocyte integrins. We showed recently that this activity dampens neutrophil recruitment into inflamed tissue and is required for survival of myocardial infarction in mice. The receptor responsible for this GDF-15-triggered anti-inflammatory mechanism on myeloid cells is not known. Here, we identify this receptor as transforming growth factor β receptor I (TGF-βRI) (activin… CONTINUE READING
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Contrasting mechanisms for suppression of macrophage cytokine release by transforming 540 ARTZ et al BLOOD, 28 JULY 2016 x VOLUME 128, NUMBER 4 For personal use

  • C Bogdan, J Paik, Y Vodovotz, C. Nathan
  • only. on September
  • 2016
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