GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria.

@article{Pedrola2005GDAP1TP,
  title={GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria.},
  author={L. Pedrola and A. Espert and Xingyao Wu and R. Claramunt and M. Shy and F. Palau},
  journal={Human molecular genetics},
  year={2005},
  volume={14 8},
  pages={
          1087-94
        }
}
Mutations in GDAP1, the ganglioside-induced differentiation-associated protein 1 gene, cause Charcot-Marie-Tooth (CMT) type 4A, a severe autosomal recessive form of neuropathy associated with either demyelinating or axonal phenotypes. Here, we demonstrate that GDAP1 has far greater expression in neurons than in myelinating Schwann cells. We investigated cell localization of GDAP1 in a human neuroblastoma cell line by means of transient overexpression and co-localization with organelle markers… Expand
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