GD3-replica peptides selected from a phage peptide library induce a GD3 ganglioside antibody response.

@article{Popa2006GD3replicaPS,
  title={GD3-replica peptides selected from a phage peptide library induce a GD3 ganglioside antibody response.},
  author={Iuliana Popa and Dai Ishikawa and Michinori Tanaka and Koichi Ogino and Jacques Portoukalian and Takao Taki},
  journal={FEBS letters},
  year={2006},
  volume={580 5},
  pages={1398-404}
}
GD3-replica peptides were obtained from a phage peptide library and an anti-GD3 monoclonal antibody (Mab) (4F6), and anti-GD3 Mabs were generated by immunizing a peptide GD3P4. A Mab, 3D2 was found to recognize GD3 by immunohistochemical approaches. Amino acid analysis of heavy and light chain variable regions of 4F6 and 3D2 showed that the respective chains had the same length, and only a few different amino acid substitutions were found. The present data indicate that the immunogenic GD3P4 is… CONTINUE READING