GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis.

@article{Qin2017GD1aOI,
  title={GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis.},
  author={Jing Qin and Arend H Sikkema and Kristine van der Bij and Jenny C. de Jonge and Karin Klappe and Vera J. M. Nies and Johan W. Jonker and Jan Willem Kok and Dick Hoekstra and Wia Baron},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2017},
  volume={37 41},
  pages={9925-9938}
}
Remyelination failure by oligodendrocytes contributes to the functional impairment that characterizes the demyelinating disease multiple sclerosis (MS). Since incomplete remyelination will irreversibly damage axonal connections, treatments effectively promoting remyelination are pivotal in halting disease progression. Our previous findings suggest that fibronectin aggregates, as an environmental factor, contribute to remyelination failure by perturbing oligodendrocyte progenitor cell (OPC… CONTINUE READING
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