GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.

@article{Kikuchi2011GCN5RT,
  title={GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.},
  author={Hidehiko Kikuchi and Futoshi Kuribayashi and Yasunari Takami and Shinobu Imajoh-ohmi and Tatsuo Nakayama},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={405 4},
  pages={657-61}
}
Histone acetyltransferase(s) (HATs) are involved in the acetylation of core histones, which is an important event for transcription regulation through alterations in the chromatin structure in eukaryotes. General control non-depressible 5 (GCN5) was first identified as a global coactivator and transcription-related HAT. Here we report that GCN5 regulates the activation of phosphatidylinositol 3-kinase (PI3K)/acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) survival pathway… CONTINUE READING