GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.

@article{Kikuchi2011GCN5RT,
  title={GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk.},
  author={H. Kikuchi and F. Kuribayashi and Y. Takami and S. Imajoh-ohmi and T. Nakayama},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={405 4},
  pages={
          657-61
        }
}
  • H. Kikuchi, F. Kuribayashi, +2 authors T. Nakayama
  • Published 2011
  • Medicine, Biology
  • Biochemical and biophysical research communications
  • Histone acetyltransferase(s) (HATs) are involved in the acetylation of core histones, which is an important event for transcription regulation through alterations in the chromatin structure in eukaryotes. General control non-depressible 5 (GCN5) was first identified as a global coactivator and transcription-related HAT. Here we report that GCN5 regulates the activation of phosphatidylinositol 3-kinase (PI3K)/acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) survival pathway… CONTINUE READING
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