GCN5-dependent acetylation of HIV-1 integrase enhances viral integration

@inproceedings{Terreni2009GCN5dependentAO,
  title={GCN5-dependent acetylation of HIV-1 integrase enhances viral integration},
  author={Mariaelena Terreni and Vania Liverani and Mar{\'i}a In{\'e}s Guti{\'e}rrez and Cristina Di Primio and Armida Di Fenza and Valentina Tozzini and Alberto Albanese and Daniele Arosio and Mauro Giacca and Anna Cereseto},
  booktitle={Retrovirology},
  year={2009}
}
BackgroundAn essential event during the replication cycle of HIV-1 is the integration of the reverse transcribed viral DNA into the host cellular genome. Our former report revealed that HIV-1 integrase (IN), the enzyme that catalyzes the integration reaction, is positively regulated by acetylation mediated by the histone acetyltransferase (HAT) p300.ResultsIn this study we demonstrate that another cellular HAT, GCN5, acetylates IN leading to enhanced 3'-end processing and strand transfer… CONTINUE READING

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