GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.

@article{Lerin2006GCN5AC,
  title={GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha.},
  author={Carles Lerin and Joseph T. Rodgers and D{\'a}rio Eluan Kalume and Seung-hee Kim and Akhilesh Pandey and Pere B. Puigserver},
  journal={Cell metabolism},
  year={2006},
  volume={3 6},
  pages={429-38}
}
Hormonal and nutrient regulation of hepatic gluconeogenesis mainly occurs through modulation of the transcriptional coactivator PGC-1alpha. The identity of endogenous proteins and their enzymatic activities that regulate the functions and form part of PGC-1alpha complex are unknown. Here, we show that PGC-1alpha is in a multiprotein complex containing the acetyltransferase GCN5. PGC-1alpha is directly acetylated by GCN5 resulting in a transcriptionally inactive protein that relocalizes from… CONTINUE READING
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