GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

@article{Hope1987GCN4AE,
  title={GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.},
  author={Ian A Hope and Kevin Struhl},
  journal={The EMBO journal},
  year={1987},
  volume={6 9},
  pages={2781-4}
}
The eukaryotic transcriptional activator protein, GCN4, synthesized in vitro from the cloned gene, binds specifically to the promoters of yeast amino acid biosynthetic genes. Previous analysis of truncated GCN4 derivatives localized the DNA binding domain to the C-terminal 60 amino acids and revealed that the size of the GCN4 derivative and the electrophoretic mobility of the protein-DNA complex were inversely related. This observation was utilized here to develop a novel method for determining… CONTINUE READING

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