GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi

  title={GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi},
  author={Amaranta Muniz Malvezzi and Mirella {\'A}rico and Normanda Souza-Melo and Gregory Pedroso dos Santos and Paula Bittencourt-Cunha and Fabiola B Holetz and Sergio Schenkman},
  journal={Frontiers in Cellular and Infection Microbiology},
The integrated stress response in eukaryotic cells is an orchestrated pathway that leads to eukaryotic Initiation Factor 2 alpha subunit (eIF2α) phosphorylation at ser51 and ultimately activates pathways to mitigate cellular damages. Three putative kinases (Tck1, Tck2, and Tck3) are found in the Trypanosoma cruzi genome, the flagellated parasite that causes Chagas disease. These kinases present similarities to other eukaryotic eIF2α kinases, exhibiting a typical insertion loop in the kinase… 

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