GCF2: expression and molecular analysis of repression.

  title={GCF2: expression and molecular analysis of repression.},
  author={Toshiki Rikiyama and Joseph Curtis and Masaya Oikawa and Drazen B. Zimonjic and Nicholas Popescu and Barbara A. Murphy and Melissa Ann Wilson and Alfred C. Johnson},
  journal={Biochimica et biophysica acta},
  volume={1629 1-3},
GC-binding factor 2 (GCF2) is a transcriptional repressor that decreases activity of the epidermal growth factor receptor (EGFR) and other genes. We have mapped the gene for GCF2 by fluorescence in situ hybridization (FISH) to chromosome 2q37. Sequence analysis of the GCF2 gene and cDNA showed that the gene consists of eight exons and introns and spans 73 kbp of DNA. Northern blot analysis showed that GCF2 mRNA was differentially expressed in many human tissues and cell lines. GCF2 mRNA was… CONTINUE READING
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