GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae.

@article{Calvo1999GCD14pAR,
  title={GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae.},
  author={Olga Calvo and Rafael Reyes Cuesta and Jessica Anderson and Natalia {\'A}ngel Guti{\'e}rrez and Minerva T. GARCIA-BARRIO and Alan G Hinnebusch and M Tamame},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 6},
  pages={
          4167-81
        }
}
Gcd10p and Gcd14p were first identified genetically as repressors of GCN4 mRNA translation in Saccharomyces cerevisiae. Recent findings indicate that Gcd10p and Gcd14p reside in a nuclear complex required for the presence of 1-methyladenosine in tRNAs. Here we show that Gcd14p is an essential protein with predicted binding motifs for S-adenosylmethionine, consistent with a direct function in tRNA methylation. Two different gcd14 mutants exhibit defects in cell growth and accumulate high levels… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

La Protein and the Trafficking of Nascent RNA Polymerase III Transcripts

  • The Journal of cell biology
  • 2001
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

tRNA transfers to the limelight.

  • Genes & development
  • 2003
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED