GC skew and mitochondrial origins of replication.

  title={GC skew and mitochondrial origins of replication.},
  author={Abdullah H. Sahyoun and Matthias Bernt and Peter F. Stadler and Kifah R. Tout},
The comprehensive understanding of mitochondrial genome evolution requires a detailed mechanistic picture of mitogenomic replication. Despite many previous efforts it has remained a non-trivial problem to determine the origins of replication and trace their fate across rearrangements of the gene order even in the small genomes of animal mitochondria. We elaborate here on the observation that the GC skew is correlated with the distance from the replication origins. This effect has been explained… CONTINUE READING


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