GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells

  title={GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells},
  author={Eric M. Mendenhall and Richard Koche and Thanh Truong and Vicky W. Zhou and Biju Issac and Andrew Chi and Manching M Ku and Bradley E. Bernstein},
  booktitle={PLoS genetics},
Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements by DNA binding proteins associated with Polycomb repressive complex 2 (PRC2). However, the sequences that recruit PRC2 in mammalian cells have remained obscure. To address this, we integrated a series of engineered bacterial artificial chromosomes into embryonic stem (ES) cells… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS