GC-IMS headspace analyses allow early recognition of bacterial growth and rapid pathogen differentiation in standard blood cultures

@article{Drees2019GCIMSHA,
  title={GC-IMS headspace analyses allow early recognition of bacterial growth and rapid pathogen differentiation in standard blood cultures},
  author={Carolin Drees and Wolfgang Vautz and Sascha Liedtke and Christophe Rosin and Kirsten Althoff and Martin Lippmann and Stefan Zimmermann and Tobias J. Legler and Duygu Yildiz and Thorsten Perl and Nils Kunze-Szikszay},
  journal={Applied Microbiology and Biotechnology},
  year={2019},
  volume={103},
  pages={9091 - 9101}
}
Outcome of patients with blood stream infections (BSI) depends on the rapid initiation of adequate antibiotic therapy, which relies on the fast and reliable identification of the underlying pathogen. Blood cultures (BC) using CO2-sensitive colorimetric indicators and subsequent microbiological culturing are the diagnostic gold standard but turnaround times range between 24 and 48 h. The detection of volatile organic compounds of microbial origin (mVOC) has been described as a feasible method… 
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