GC/AT-content spikes as genomic punctuation marks.

@article{Zhang2004GCATcontentSA,
  title={GC/AT-content spikes as genomic punctuation marks.},
  author={Lingang Zhang and Simon Kasif and Charles R. Cantor and Natalia E. Broude},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 48},
  pages={16855-60}
}
Large-scale analysis of the GC-content distribution at the gene level reveals both common features and basic differences in genomes of different groups of species. Sharp changes in GC content are detected at the transcription boundaries for all species analyzed, including human, mouse, rat, chicken, fruit fly, and worm. However, two substantially distinct groups of GC-content profiles can be recognized: warm-blooded vertebrates including human, mouse, rat, and chicken, and invertebrates… CONTINUE READING
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