GBV-C viremia is associated with reduced CD4 expansion in HIV-infected people receiving HAART and interleukin-2 therapy.

@article{Stapleton2009GBVCVI,
  title={GBV-C viremia is associated with reduced CD4 expansion in HIV-infected people receiving HAART and interleukin-2 therapy.},
  author={Jack T. Stapleton and Kathryn Chaloner and Jingyang Zhang and Donna Klinzman and Inara Espinelli L Souza and Jinhua Xiang and Alan L. Landay and John Fahey and Richard Pollard and Ronald Mitsuyasu},
  journal={AIDS},
  year={2009},
  volume={23 5},
  pages={605-10}
}
OBJECTIVE Interleukin-2 (IL-2) is a cytokine with multiple effects on lymphocytes including induction of CD4 T-cell proliferation. IL-2 administration has been shown to increase CD4 cell counts in HIV-infected people receiving antiretroviral therapy. GB virus C (GBV-C) is an apparently nonpathogenic flavivirus that replicates in CD4 T cells and inhibits HIV replication in vitro by mechanisms including downregulation of HIV entry coreceptors (CCR5 and CXCR4) and induction of chemokines (RANTES… CONTINUE READING