GBA-associated Parkinson's disease: reduced survival and more rapid progression in a prospective longitudinal study.

@article{Brockmann2015GBAassociatedPD,
  title={GBA-associated Parkinson's disease: reduced survival and more rapid progression in a prospective longitudinal study.},
  author={Kathrin Brockmann and Karin Srulijes and Sylvia Pflederer and A K Hauser and Claudia Schulte and Walter Maetzler and Thomas Gasser and D. Berg},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2015},
  volume={30 3},
  pages={407-11}
}
BACKGROUND Parkinson's disease (PD) patients with GBA mutations show an earlier age at onset and more severe non-motor symptoms compared with PD patients without GBA mutations. OBJECTIVE This study was undertaken to evaluate progression of motor and non-motor symptoms in sporadic PD patients depending on the mutational GBA status. METHODS We used regression analysis to evaluate independent effects of the mutational GBA status, age at onset, age at examination, and disease duration on motor… CONTINUE READING
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