GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates.

@article{Mohr2010GBVT,
  title={GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates.},
  author={Emma L Mohr and Jinhua Xiang and James H. McLinden and Thomas M. Kaufman and Qing Chang and David C. Montefiori and Donna Klinzman and Jack T. Stapleton},
  journal={Journal of immunology},
  year={2010},
  volume={185 7},
  pages={
          4496-505
        }
}
Broadly neutralizing Abs to HIV-1 are well described; however, identification of Ags that elicit these Abs has proven difficult. Persistent infection with GB virus type C (GBV-C) is associated with prolonged survival in HIV-1-infected individuals, and among those without HIV-1 viremia, the presence of Ab to GBV-C glycoprotein E2 is also associated with survival. GBV-C E2 protein inhibits HIV-1 entry, and an antigenic peptide within E2 interferes with gp41-induced membrane perturbations in vitro… CONTINUE READING

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