GB toxicity reassessed using newer techniques for estimation of human toxicity from animal inhalation toxicity data: New method for estimating acute human toxicity (GB)

@article{Bide2005GBTR,
  title={GB toxicity reassessed using newer techniques for estimation of human toxicity from animal inhalation toxicity data: New method for estimating acute human toxicity (GB)},
  author={R. W. Bide and S. Armour and E. Yee},
  journal={Journal of Applied Toxicology},
  year={2005},
  volume={25}
}
  • R. W. Bide, S. Armour, E. Yee
  • Published 2005
  • Chemistry, Medicine
  • Journal of Applied Toxicology
  • Estimated human inhalation toxicity values for Sarin (GB) were calculated using a new two independent (concentration, exposure time), one dependent (toxic response), non‐linear dose response (toxicity) model combined with re‐evaluated allometric equations relating to animal and human respiration. Historical animal studies of GB toxicity containing both exposure and fractional animal response data were used to test the new process. The final data set contained 6621 animals, 762 groups, 37… CONTINUE READING
    13 Citations
    Inhalation toxicology: methodological and regulatory challenges.
    • J. Pauluhn
    • Chemistry, Medicine
    • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
    • 2008
    • 24
    Consequence assessment of indoor dispersion of sarin--a hypothetical scenario.
    • 16
    Prenatal exposure to diesel exhaust PM2.5 causes offspring β cell dysfunction in adulthood.
    • 6

    References

    SHOWING 1-10 OF 41 REFERENCES
    Problems in extrapolating toxicity data for laboratory animals to man.
    • R. Dixon
    • Biology, Medicine
    • Environmental health perspectives
    • 1976
    • 36
    Inhalation toxicity in mice exposed to sarin (GB) for 20–720 min
    • 17
    An up-and-down procedure for acute toxicity testing.
    • R. Bruce
    • Medicine
    • Fundamental and applied toxicology : official journal of the Society of Toxicology
    • 1985
    • 266