GATES: a rapid and powerful gene-based association test using extended Simes procedure.

  title={GATES: a rapid and powerful gene-based association test using extended Simes procedure.},
  author={Miao-Xin Li and Hong-sheng Gui and Johnny S. H. Kwan and Pak C. Sham},
  journal={American journal of human genetics},
  volume={88 3},
The gene has been proposed as an attractive unit of analysis for association studies, but a simple yet valid, powerful, and sufficiently fast method of evaluating the statistical significance of all genes in large, genome-wide datasets has been lacking. Here we propose the use of an extended Simes test that integrates functional information and association evidence to combine the p values of the single nucleotide polymorphisms within a gene to obtain an overall p value for the association of… CONTINUE READING
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