GATE as a GEANT4-based Monte Carlo platform for the evaluation of proton pencil beam scanning treatment plans

  title={GATE as a GEANT4-based Monte Carlo platform for the evaluation of proton pencil beam scanning treatment plans},
  author={Lo{\"i}c Grevillot and Damien Bertrand and Franz Dessy and Nicolas Freud and David Sarrut},
  journal={Physics in Medicine and Biology},
  pages={4223 - 4244}
Active scanning delivery systems take full advantage of ion beams to best conform to the tumor and to spare surrounding healthy tissues; however, it is also a challenging technique for quality assurance. In this perspective, we upgraded the GATE/GEANT4 Monte Carlo platform in order to recalculate the treatment planning system (TPS) dose distributions for active scanning systems. A method that allows evaluating the TPS dose distributions with the GATE Monte Carlo platform has been developed and… 

A GATE/Geant4 beam model for the MedAustron non-isocentric proton treatment plans quality assurance.

  • A. EliaA. Resch L. Grevillot
  • Physics, Medicine
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2020

Evaluation of clinical IMRT treatment planning using the GATE Monte Carlo simulation platform for absolute and relative dose calculations.

The results show that GATE allows reliable simulation of complex beams in radiotherapy after an accurate LINAC modeling is validated and a simple cross-calibration procedure proposed in this work allows obtaining absolute dose values even in complex fields.

Validation and testing of a novel pencil-beam model derived from Monte Carlo simulations in carbon-ion treatment planning for different scenarios.

  • Hui ZhangQiang Li G. Xiao
  • Medicine, Physics
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
  • 2022

Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam

This work aims to validate the nuclear models employed by the Geant4 MC code, by comparing the simulated absolute dose distribution to a recent experiment of a 177 MeV proton pencil beam stopping in water.

Implementation of a Compact Spot-Scanning Proton Therapy System in a GPU Monte Carlo Code to Support Clinical Routine

A fast Monte Carlo dose calculation tool in the Maastro proton therapy center in Maastricht (Netherlands) to complement the clinical treatment planning system, Fred, which achieves high accuracy and computation speed by using physics models optimized for radiotherapy and extensive use of GPU technology for parallelization.

Development of the DICOM-based Monte Carlo dose reconstruction system for a retrospective study on the secondary cancer risk in carbon ion radiotherapy

A new dose reconstruction system based on the Particle and Heavy Ion Transport code System (PHITS) coupled with the treatment plan DICOM data set is developed by extending the functionalities of RadioTherapy package based on PHITS (RT-PHITS).

Treatment planning aspects and Monte Carlo methods in proton therapy

Monte Carlo dose calculation algorithms are expected to improve the accuracy of the calculated dose distributions and to be introduced in clinical routine in the near future.

Improved calibration of mass stopping power in low density tissue for a proton pencil beam algorithm

It is suggested that the MA formula is adopted by users of the pencil beam algorithm for optimal dose calculation in lung, and that a similar approach is considered when beams traverse other low density regions such as the paranasal sinuses and mastoid process.

Technical Note: validation of a material assignment method for a retrospective study of carbon-ion radiotherapy using Monte Carlo simulation

A two-step method to converse human tissue materials from patient computed tomography images, which is required in dose reconstructions for a retrospective study of carbon-ion radiotherapy (CIRT) using Monte Carlo (MC) simulation, and good agreement of the depth-dose distributions between the TPS and MC simulation was obtained.



Optimization of GEANT4 settings for Proton Pencil Beam Scanning simulations using GATE

A Monte Carlo pencil beam scanning model for proton treatment plan simulation using GATE/GEANT4

This work proposes a generic method for modeling scanned ion beam delivery systems, without simulation of the treatment nozzle and based exclusively on beam data library (BDL) measurements required

Clinical implementation of full Monte Carlo dose calculation in proton beam therapy

The goal of this work was to facilitate the clinical use of Monte Carlo proton dose calculation to support routine treatment planning and delivery and to describe the general challenges and considerations when implementing proton Monte Carlo dose calculation in a clinical environment.

Monte Carlo Simulation of 6MV Elekta Synergy Platform Linac photon beam using Gate/Geant4

A computational model using the Gate Monte Carlo software for the simulation of a 6MV photon beam given by Elekta Synergy Platform medical linear accelerator treatment head is developed, which includes the major components of the multileaf accelerator head and a homogeneous water phantom.

A pencil beam algorithm for intensity modulated proton therapy derived from Monte Carlo simulations

A pencil beam algorithm as a component of an optimization algorithm for intensity modulated proton therapy (IMPT) is presented, and dose distributions are benchmarked against Monte Carlo simulations, showing 3%/1 mm agreement for simple heterogeneous phantoms and principal shortcomings of pencil beam algorithms are evident.

A treatment planning inter-comparison of proton and intensity modulated photon radiotherapy.

  • A. LomaxT. Bortfeld R. Mirimanoff
  • Physics, Medicine
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 1999

Simulation of a 6 MV Elekta Precise Linac photon beam using GATE/GEANT4

The selective bremsstrahlung splitting (SBS) variance reduction technique proposed in GATE was used in order to speed up the accelerator head simulation and showed that the SBS can be safely used without biasing the simulations.

A Monte Carlo dose calculation algorithm for proton therapy.

A Monte Carlo (MC) code (VMCpro) for treatment planning in proton beam therapy of cancer is introduced. It is based on ideas of the Voxel Monte Carlo algorithm for photons and electrons and is

Treatment planning and verification of proton therapy using spot scanning: initial experiences.

Field specific dosimetry shows that these treatments can be delivered accurately and precisely to within +/-1 mm (1 SD) orthogonal to the field direction and to within 1.5 mm in range, indicating the flexibility of the spot scanning system for treating lesions of all types and sizes.

Assigning nonelastic nuclear interaction cross sections to Hounsfield units for Monte Carlo treatment planning of proton beams

A scaling curve for nonelastic nuclear interactions as a function of Hounsfield unit has been established and compared with similar data for the stopping powers and Monte Carlo simulations in slab geometries with tissue materials for 200 MeV protons showSimilar effects, but when both contributions are scaled correctly the errors are not larger than 0.5%.