GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice.

Abstract

In response to gonadectomy certain inbred mouse strains develop sex steroidogenic adrenocortical neoplasms. One of the hallmarks of neoplastic transformation is expression of GATA4, a transcription factor normally present in gonadal but not adrenal steroidogenic cells of the adult mouse. To show that GATA4 directly modulates adrenocortical tumorigenesis and… (More)
DOI: 10.1210/en.2011-2135

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