GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness.

@article{Gaynor2013GATA3MF,
  title={GATA3 mutations found in breast cancers may be associated with aberrant nuclear localization, reduced transactivation and cell invasiveness.},
  author={Katherine U Gaynor and Irina V Grigorieva and Michael D Allen and Christopher T. Esapa and Rosemary A. Head and Preethi Gopinath and Paul T. Christie and M Andrew Nesbit and J. Louise Jones and Rajesh V Thakker},
  journal={Hormones & cancer},
  year={2013},
  volume={4 3},
  pages={123-39}
}
Somatic and germline mutations in the dual zinc-finger transcription factor GATA3 are associated with breast cancers expressing the estrogen receptor (ER) and the autosomal dominant hypoparathyroidism-deafness-renal dysplasia syndrome, respectively. To elucidate the role of GATA3 in breast tumorigenesis, we investigated 40 breast cancers that expressed ER, for GATA3 mutations. Six different heterozygous GATA3 somatic mutations were identified in eight tumors, and these consisted of: a… CONTINUE READING
Highly Cited
This paper has 21 citations. REVIEW CITATIONS