GATA3 is downregulated during hair cell differentiation in the mouse cochlea.

GATA3 is a transcription factor expressed in the inner ear during the early stages of development. A monoclonal antibody revealed that it is expressed in spiral ganglion cells and in all cells of the developing auditory sensory epithelium in the mouse before the hair cells differentiate at embryonic days 14-16. Expression decreases selectively in the hair… CONTINUE READING