GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler

@inproceedings{Takaku2016GATA3dependentCR,
  title={GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler},
  author={Motoki Takaku and Sara A. Grimm and Takashi Shimbo and Lalith Perera and Roberta Menafra and Hendrik G. Stunnenberg and Trevor K Archer and Shinichi Machida and Hitoshi Kurumizaka and Paul A Wade},
  booktitle={Genome Biology},
  year={2016}
}
Transcription factor-dependent cellular reprogramming is integral to normal development and is central to production of induced pluripotent stem cells. This process typically requires pioneer transcription factors (TFs) to induce de novo formation of enhancers at previously closed chromatin. Mechanistic information on this process is currently sparse. Here we explore the mechanistic basis by which GATA3 functions as a pioneer TF in a cellular reprogramming event relevant to breast cancer, the… CONTINUE READING
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