GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea.

@article{Luo2013GATA3CT,
  title={GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea.},
  author={Xiong-Jian Luo and Min Deng and Xiaoling Xie and Liang Huang and Hui Wang and Lichun Jiang and Guoqing Liang and Fang Hu and Roger Tieu and Rui Chen and Lin Gan},
  journal={Human molecular genetics},
  year={2013},
  volume={22 18},
  pages={3609-23}
}
HDR syndrome (also known as Barakat syndrome) is a developmental disorder characterized by hypoparathyroidism, sensorineural deafness and renal disease. Although genetic mapping and subsequent functional studies indicate that GATA3 haplo-insufficiency causes human HDR syndrome, the role of Gata3 in sensorineural deafness and auditory system development is largely unknown. In this study, we show that Gata3 is continuously expressed in the developing mouse inner ear. Conditional knockout of Gata3… CONTINUE READING
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