GATA-related hematologic disorders.

  title={GATA-related hematologic disorders.},
  author={Ritsuko Shimizu and Masayuki Yamamoto},
  journal={Experimental hematology},
  volume={44 8},
The transcription factors GATA1 and GATA2 are fundamental regulators of hematopoiesis and have overlapping expression profiles. GATA2 is expressed in hematopoietic stem cells and early erythroid-megakaryocytic progenitors and activates a certain set of early-phase genes, including the GATA2 gene itself. GATA2 also initiates GATA1 gene expression. In contrast, GATA1 is expressed in relatively mature erythroid progenitors and facilitates the expression of genes associated with differentiation… CONTINUE READING
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