GATA-dependent recruitment of MEF2 proteins to target promoters.

  title={GATA-dependent recruitment of MEF2 proteins to target promoters.},
  author={Steves Morin and F{\'e}rd{\'e}ric Charron and Lynda Robitaille and Mona Nemer},
  journal={The EMBO journal},
  volume={19 9},
The myocyte enhancer factor-2 (MEF2) proteins are MADS-box transcription factors that are essential for differentiation of all muscle lineages but their mechanisms of action remain largely undefined. In mammals, the earliest site of MEF2 expression is the heart where the MEF2C isoform is detectable as early as embryonic day 7.5. Inactivation of the MEF2C gene causes cardiac developmental arrest and severe downregulation of a number of cardiac markers including atrial natriuretic factor (ANF… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 132 extracted citations

Similar Papers

Loading similar papers…