GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype: Results from the TREP Project

@inproceedings{Virgone2012GATA4AF,
  title={GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype: Results from the TREP Project},
  author={Calogero Virgone and Giovanni Cecchetto and Andrea Ferrari and Gianni Bisogno and Vittoria Donofrio and Renata Boldrini and Paola Collini and Patrizia Dall’Igna and Rita D Alaggio},
  booktitle={PloS one},
  year={2012}
}
AIM GATA proteins are a family of zinc finger transcription factors regulating gene expression, differentiation and proliferation in various tissues. The expression of GATA-4 and FOG-2, one of its modulators, was studied in pediatric Sex Cord-Stromal tumors of the ovary, in order to evaluate their potential role as diagnostic markers and prognostic factors. MATERIALS AND METHODS Clinical and histological data of 15 patients, enrolled into the TREP Project since 2000 were evaluated. When… CONTINUE READING

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