GATA-3 regulates the homeostasis and activation of CD8+ T cells.

  title={GATA-3 regulates the homeostasis and activation of CD8+ T cells.},
  author={Tzong-Shyuan Tai and Sung-Yun Pai and I -Ching Ho},
  journal={Journal of immunology},
  volume={190 1},
GATA-3, a C2C2-type zinc finger transcription factor, regulates many steps of T cell development and differentiation. It is also required for optimal production of type 2 cytokines by CD8(+) T cells. However, its role in the development and function of this subset of T cells is still poorly characterized. In this paper, we report that GATA-3 is required for MHC-mediated positive selection and final maturation of CD8 single-positive thymocytes. Deficiency of GATA-3 mediated by a CD4cre transgene… CONTINUE READING
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