GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.

@article{Onodera1997GATA1TI,
  title={GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.},
  author={Kazuyuki Onodera and Satoru Takahashi and Susumu Nishimura and Jun Ohta and Hozumi Motohashi and Kentaro Yomogida and Natsuko Hayashi and James Douglas Engel and Masayuki Yamamoto},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 9},
  pages={4487-92}
}
Transcription factor GATA-1 is required for the terminal differentiation of both the primitive and definitive erythroid cell lineages, and yet the regulatory mechanisms of GATA-1 itself are not well understood. To clarify how the GATA-1 gene is transcriptionally controlled in vivo, presumptive regulatory regions of the gene were tested by fusion to a reporter gene and then examined in transgenic mice. We found that a transcriptional control element located between -3.9 and -2.6 kb 5' to the… CONTINUE READING