GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells

@article{Huang2005GATA1MA,
  title={GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells},
  author={Duen-Yi Huang and Yuan-Yeh Kuo and Z T Chang},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={5331 - 5342}
}
Gfi-1B (growth factor independence-1B) gene is an erythroid-specific transcription factor, whose expression plays an essential role in erythropoiesis. Our laboratory has previously defined the human Gfi-1B promoter region and shown that GATA-1 mediates erythroid-specific Gfi-1B transcription. By further investigating the regulation of the Gfi-1B promoter, here we report that (i) Gfi-1B transcription is negatively regulated by its own gene product, (ii) GATA-1, instead of Gfi-1B, binds directly… CONTINUE READING
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