GASTRODUODENAL TOXICITY OF DIFFERENT NONSTEROIDAL ANTIINFLAMMATORY DRUGS

@article{Traversa1995GASTRODUODENALTO,
  title={GASTRODUODENAL TOXICITY OF DIFFERENT NONSTEROIDAL ANTIINFLAMMATORY DRUGS},
  author={G. Traversa and A. Walker and F. Ippolito and B. Caffari and L. Capurso and A. Dezi and M. Koch and M. Maggini and S. S. Alegiani and R. Raschetti},
  journal={Epidemiology},
  year={1995},
  volume={6},
  pages={49–54}
}
Although the etiologic relation between nonsteroidal antiinflammatory drug (NSAID) use and gastrointestinal lesions is well documented, newly introduced NSAIDs deserve a fresh examination for their risk/benefit ratio. To estimate the association between consumption of ketorolac and the occurrence of gastroduodenal lesions, we conducted a case-control study. The study population comprised 600 outpatients with a confirmed endoscopic diagnosis of ulcer and erosion in 1991 and 1992 and 6,000… Expand
Ketorolac use in outpatients and gastrointestinal hospitalization: a comparison with other non-steroidal anti-inflammatory drugs in Italy
TLDR
The study demonstrates the need to adhere to the restrictions relating to the indications and duration of use of ketorolac and represents a greater public health concern since it is confirmed to be among the most gastrotoxic NSAIDs and is one of the most commonly prescribed NSAIDs in Italy. Expand
Risk of uncomplicated peptic ulcer among users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs.
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The risk of symptomatic ulcer for aspirin and nonaspirin NSAIDs was elevated throughout treatment, suggesting that NSAIDs might not only complicate but also originate clinically relevant peptic ulcers. Expand
Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s.
TLDR
The elderly and patients with a history of peptic ulcer could benefit the most from a reduction in NSAID gastrotoxicity, especially in the subgroup of patients with the greatest background risk. Expand
Risk of hospitalization for upper gastrointestinal bleeding associated with ketorolac, other NSAIDs, calcium antagonists and other antihypertensive drugs
TLDR
The large excess risk of major upper gastrointestinal complications associated with outpatient use of ketorolac suggests an unfavourable risk/benefitevaluation compared to other NSAIDs. Expand
Upper Gastrointestinal Bleeding Associated with the Use of NSAIDs
TLDR
The risk of upper gastrointestinal bleeding associated with NSAIDs and analgesics, with special emphasis on those agents that have been introduced in recent years, is a common cause of hospital admission and its risk depends on the particular drug and its dose, and on concomitant treatments. Expand
Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs.
TLDR
The excess risk of major upper gastrointestinal tract complications associated with outpatient use of ketorolac suggests an unfavorable risk-benefit assessment compared with other NSAIDs. Expand
Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs
TLDR
The risk of liver injury in patients taking nimesulide and other non-steroidal anti-inflammatory drugs is small and the rate ratio for all hepatopathies and more severe liver injury was 1.3 to 1.4. Expand
Nonselective Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Gastrointestinal Bleeding: Relative and Absolute Risk Estimates From Recent Epidemiologic Studies
TLDR
GIB risk declines following cessation of NNANSAID use, with current rather than prior cumulative exposure the key determinant of risk. Expand
Utilisation Pattern of Nonspecific Nonsteroidal Anti-Inflammatory Drugs and COX-2 Inhibitors in a Local Health Service Unit in Northeast Italy
TLDR
Analysis of an administrative database in Italy showed a trend suggesting that COXIBs are prescribed to an older population and for a longer period of time than NS-NSAIDs, and that their use is less frequently associated with GPAs. Expand
A Case of Unexplained Duodenal Ulcer and Massive Gastrointestinal Bleed.
TLDR
The patient's concurrent exposure to multiple NSAIDs significantly increased the risk of upper GI complications and it is reasonable to argue that the high-dose use of the NSAIDs was a major cause of the duodenal ulcer and GI bleed. Expand
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The data support other findings indicating that a clinically significant risk for serious ulcer disease is associated with the use of nonaspirin nonsteroidal anti-inflammatory drugs and that use of these drugs may be responsible for a large proportion of peptic ulcers among elderly persons. Expand
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Differences in drug intake were evident for both gastric and duodenal ulcer, and are likely to be important in view of the widespread use of these drugs in elderly people. Expand
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