GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.

@article{Shiozawa2010GAS6AXLAR,
  title={GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.},
  author={Yusuke Shiozawa and Elisabeth A. Pedersen and Lalit R. Patel and Anne Marie Ziegler and Aaron M. Havens and Younghun Jung and Jingcheng Wang and Stephanie Zalucha and Robert D. Loberg and Kenneth J. Pienta and Russell S Taichman},
  journal={Neoplasia},
  year={2010},
  volume={12 2},
  pages={116-27}
}
Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche. Similarly, prostate cancer (PCa) cells express the annexin II receptor and seem to use the stem cell niche for homing to the bone marrow. The role of the niche is thought to be the induction and sustenance of HSC dormancy. If metastatic PCa cells occupy a similar or the same ecological niche as HSCs, then… CONTINUE READING