GAPs in growth factor signalling.

@article{Bernards2005GAPsIG,
  title={GAPs in growth factor signalling.},
  author={Andre Bernards and Jeffrey Settleman},
  journal={Growth factors},
  year={2005},
  volume={23 2},
  pages={
          143-9
        }
}
Approximately 2% of genes predicted by the sequenced human genome encode small GTPases and their regulators, highlighting the biological significance of regulated GTPase activity. Among the key GTPase regulators are the GTPase activating proteins (GAPs), which function to down-modulate active GTPases. Of the numerous identified GAPs, several have been implicated in signal transduction downstream of growth factors. In particular, GAPs for the Ras and Rho GTPases, which mediate a variety of… CONTINUE READING

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