GAPDH knockdown rescues mesencephalic dopaminergic neurons from MPP+ -induced apoptosis.

@article{Fukuhara2001GAPDHKR,
  title={GAPDH knockdown rescues mesencephalic dopaminergic neurons from MPP+ -induced apoptosis.},
  author={Y D M Fukuhara and Takao Takeshima and Yoshihiro Kashiwaya and Kouji Shimoda and Ryoichi Ishitani and Kenji Nakashima},
  journal={Neuroreport},
  year={2001},
  volume={12 9},
  pages={2049-52}
}
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12) has a number of diverse functions apart from glycolytic function. We explored the possible involvement of GAPDH in 1-methyl-4-phenylpyridinium (MPP+)-induced death of mesencephalic dopaminergic neurons (MDNs) in culture. MPP+ (10 and 20 microM, 24 h) exposure selectively decreased the survival of… CONTINUE READING