GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity.

  title={GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity.},
  author={Hilal Zaid and Ilana Talior-Volodarsky and Costin N Antonescu and Zhi Liang Liu and Amira Klip},
  journal={The Biochemical journal},
  volume={419 2},
Dietary glucose is taken up by skeletal muscle through GLUT4 (glucose transporter 4). We recently identified by MS proteins displaying insulin-dependent co-precipitation with Myc-tagged GLUT4 from L6 myotubes, including GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and HKII (hexokinase-II). In the present paper we explored whether GAPDH and HKII interact directly with cytoplasmic regions of GLUT4 and their possible inter-relationship. Endogenous and recombinant GAPDH and HKII bound to a… CONTINUE READING


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