GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

Abstract

In cells undergoing apoptosis, mitochondrial outer-membrane permeabilization (MOMP) is followed by caspase activation promoted by released cytochrome c. Although caspases mediate the apoptotic phenotype, caspase inhibition is generally not sufficient for survival following MOMP; instead cells undergo a "caspase-independent cell death" (CICD). Thus, MOMP may… (More)
DOI: 10.1016/j.cell.2007.07.012

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Cite this paper

@article{Colell2007GAPDHAA, title={GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation}, author={Anna Colell and Jean-Ehrland Ricci and Stephen W G Tait and Sandra Milasta and Ulrich Maurer and Lisa Bouchier-Hayes and Patrick Fitzgerald and Ana Gu{\'i}o-Carri{\'o}n and Nigel J. Waterhouse and Cindy Wei Li and Bernard Mari and Pascal Barbry and Donald D. Newmeyer and Helen M. Beere and Douglas R Green}, journal={Cell}, year={2007}, volume={129}, pages={983-997} }