GAPDH: Biological Properties and Diversity

  title={GAPDH: Biological Properties and Diversity},
  author={Norbert W. Seidler},
  booktitle={Advances in Experimental Medicine and Biology},
The GAPDH gene is highly conserved with a promoter that contains several types of regulatory elements, perhaps even in a distal intron. Curiously, the transcription start site shows some ambiguity and there are codon-sharing exons at alternate exon junctions. While there is only one functional gene for GAPDH in humans, the genome is littered with pseudogenes, representing a trove of researchable content. Tissue-specific expression speaks to the glycolytic function of GAPDH; thus, it’s not… CONTINUE READING