GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase.

@article{Tsang2006GAPindependentTO,
  title={GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase.},
  author={Steven H Tsang and Michael L. Woodruff and C Chen and Clyde Y Yamashita and Marianne C. Cilluffo and Anjali L Rao and Debora B Farber and Gordon L Fain},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 17},
  pages={4472-80}
}
We have generated a mouse with rod photoreceptors overexpressing the gamma inhibitory subunit (PDE6gamma) of the photoreceptor G-protein effector cGMP phosphodiesterase (PDE6). PDE6gamma overexpression decreases the rate of rise of the rod response at dim intensities, indicating a reduction in the gain of transduction that may be the result of cytoplasmic PDE6gamma binding to activated transducin alpha GTP (Talpha-GTP) before the Talpha-GTP binds to endogenous PDE6gamma. Excess PDE6gamma also… CONTINUE READING

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