GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986

@article{Gupta2009GAP43IE,
  title={GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986},
  author={Shailesh Kumar Gupta and Rashmi Mishra and Singh Kusum and Michael Spedding and Karina F. Meiri and Pierre Gressens and Shyamala Mani},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={624-637}
}
Positive α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators include benzamide compounds that allosterically modulate AMPA glutamate receptors. These small molecules that cross the blood–brain barrier have been shown to act as a neuroprotectant by increasing the levels of endogenous brain-derived neurotrophic factor (BDNF). Positive AMPA receptor modulators have also been shown to increase the levels of growth-associated protein-43 (GAP-43). GAP-43 plays a major role… CONTINUE READING

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