GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the rat.

@article{Schaden1994GAP43IA,
  title={GAP-43 immunoreactivity and axon regeneration in retinal ganglion cells of the rat.},
  author={Herbert Schaden and Claudia A. O. Stuermer and Mathias B{\"a}hr},
  journal={Journal of neurobiology},
  year={1994},
  volume={25 12},
  pages={
          1570-8
        }
}
Retinal ganglion cells (RGCs) in rats were retrogradely labeled with the fluorescent tracer Fluorogold (FG) and subjected to GAP-43 and c-JUN immunocytochemistry to identify those RGCs that are capable of regenerating an axon. After optic nerve section (ONS) and simultaneous application of FG to the nerve stump (group 1 experiments), GAP-43 immunoreactive RGCs (between 2 and 21 days after ONS) always represented a subfraction of both FG-labeled (i.e., surviving) RGCs and RGCs exhibiting c-JUN… CONTINUE READING
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