GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system.

@article{Monte1989GAP43GE,
  title={GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system.},
  author={Suzanne de la Monte and Howard J. Federoff and Siu Choon Ng and Ed Grabczyk and Mark C Fishman},
  journal={Brain research. Developmental brain research},
  year={1989},
  volume={46 2},
  pages={161-8}
}
GAP-43 is a rapidly transported axonal protein most prominently expressed in regenerating and developing nerves. However, the low level persistence of GAP-43 in the adult CNS where growth and regenerative capacity are minimal may additionally indicate a role for this molecule in neuronal remodeling. Previous studies have revealed GAP-43 immunoreactivity in neurites throughout many regions of the CNS. To identify the CNS neurons that express GAP-43 at different stages of development, we utilized… CONTINUE READING