GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth

@inproceedings{Strittmatter1994GAP43AT,
  title={GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth},
  author={S. Strittmatter and M. Igarashi and M. Fishman},
  booktitle={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994}
}
  • S. Strittmatter, M. Igarashi, M. Fishman
  • Published in
    The Journal of neuroscience…
    1994
  • Biology, Medicine
  • The neuronal growth-associated protein GAP-43 is expressed maximally during development and regeneration, and is enriched at the cytosolic surface of the growth cone membrane. GAP-43 can activate the GTP- binding protein G(o) which is also a major component of the growth cone membrane. These findings have led to the hypothesis that GAP-43 might modulate neurite outgrowth by altering G-protein activity. Here we define the sequence requirements for GAP-43 amino terminal peptide stimulation of G(o… CONTINUE READING
    Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43
    • 382
    Peripheral nerve regeneration
    • 252

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