GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth.

@article{Strittmatter1994GAP43AT,
  title={GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth.},
  author={Stephen M Strittmatter and Michihiro Igarashi and Mark C Fishman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1994},
  volume={14 9},
  pages={5503-13}
}
The neuronal growth-associated protein GAP-43 is expressed maximally during development and regeneration, and is enriched at the cytosolic surface of the growth cone membrane. GAP-43 can activate the GTP-binding protein G(o) which is also a major component of the growth cone membrane. These findings have led to the hypothesis that GAP-43 might modulate neurite outgrowth by altering G-protein activity. Here we define the sequence requirements for GAP-43 amino terminal peptide stimulation of G(o… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

GAP-43 as a neu

SM Strittmatter, T Vartanian, MC Fishman
1992
View 4 Excerpts
Highly Influenced

Activated mutants

SM Strittmatter, MC Fishman, X-P Zhu
X. laevis oocytes. Proc Nat1 Acad Sci USA • 1994

Me-diation by G proteins of signals that cause collapse of growth cones

MC IaarashiM.StrittmatterSM.VartanianT.Fishman
Science • 1993

Similar Papers

Loading similar papers…