GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.


The p53 tumor suppressor protein has a well-established role in cell-fate decision-making processes. However, recent discoveries indicate that p53 has a non-tumor-suppressive role. Here we identify guanidinoacetate methyltransferase (GAMT), an enzyme involved in creatine synthesis, as a p53 target gene and a key downstream effector of adaptive response to… (More)
DOI: 10.1016/j.molcel.2009.09.031


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