GAM: Genomic Assemblies Merger: A Graph Based Method to Integrate Different Assemblies

Abstract

Many software tools are currently available to solve the hard goal of assembling millions of fragments produced in sequencing projects. Such a variety includes packages for long and short reads, generated by classical and nextgeneration sequencing technologies. Often the result produced by different tools can diverge—sometime significantly—for many reasons: the underlying algorithm, the data structures employed, the heuristics implemented, default parameters, etc. On the ground of the above considerations, we were motivated in developing a methodology which may both guide in a comparison of different assembler’s output and improve the overall quality of the genome assembly sequences, by merging the sequences produced by different assembly programs. Keywords-DNA assemblers; Improving genomic assemblies; Data integration

DOI: 10.1109/BIBM.2009.28

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Cite this paper

@inproceedings{Casagrande2009GAMGA, title={GAM: Genomic Assemblies Merger: A Graph Based Method to Integrate Different Assemblies}, author={Alberto Casagrande and Cristian Del Fabbro and Simone Scalabrin and Alberto Policriti}, booktitle={BIBM}, year={2009} }