GALACTOSE CONSUMPTION AND METABOLISM IN RELATION TO THE RISK OF OVARIAN CANCER

@article{Cramer1989GALACTOSECA,
  title={GALACTOSE CONSUMPTION AND METABOLISM IN RELATION TO THE RISK OF OVARIAN CANCER},
  author={Daniel W. Cramer and Walter C. Willett and Debra A. Bell and Won G. Ng and Bernard L. Harlow and William R. Welch and Robert E. Scully and Robert C. Knapp},
  journal={The Lancet},
  year={1989},
  volume={334},
  pages={66-71}
}
A case-control study of galactose consumption and metabolism in relation to ovarian cancer.
  • D. Cramer, E. Greenberg, W. Ng
  • Biology
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2000
TLDR
Whereas adult consumption of lactose carries no clear risk for the disease, certain genetic or biochemical features of galactose metabolism may influence disease risk for particular types of ovarian cancer.
Milk consumption, galactose metabolism and ovarian cancer (Australia)
TLDR
The data do not support the hypothesis that galactose plays a major role in the development of ovarian cancer and suggest that reported associations between milk consumption and ovarian cancer are due to the fat content of milk and not to lactose or Galactose.
Nutritional risk factors and ovarian cancer.
TLDR
In a hospital-based case-control study, consumption of lactose-containing (dairy) foods and foods containing beta-carotene by women with epithelial cancer of the ovary and matched controls was investigated, and a protective effect of high beta-Carotene intake was indicated.
Diet and ovarian cancer risk: A case‐control study in Italy
To assess the dietary correlates of cancer of the ovary, the consumption of a wide range of food groups has been investigated in a case‐control study conducted between January 1992 and September 1999
Dairy foods and nutrients in relation to risk of ovarian cancer and major histological subtypes
TLDR
There was no evidence that lactose intake influenced ovarian cancer risk or that risk varied by tumor aggressiveness in the analyses of intake of dairy foods and nutrients, and the overall inverse association with high intake of calcium and the inverse associations of calciumand vitamin D with specific histological subtypes warrant further investigation.
Lactose absorption in patients with ovarian cancer.
TLDR
Assessment of the capacity to digest lactose by measuring breath hydrogen production after oral administration of lactose provides some support for a role for lactose ingestion and galactose cytotoxicity in the pathogenesis of ovarian cancer.
Milk/dairy products consumption, galactose metabolism and ovarian cancer: meta-analysis of epidemiological studies
TLDR
A meta-analysis of epidemiological studies related to the association between milk/dairy products consumption or galactose metabolism and ovarian cancer published between January 1966 and August 2003 found no association.
Nutritional Determinants of Epithelial Ovarian Cancer Risk: A Case-Control Study in Mexico
TLDR
The diet of the Mexican population is rich in carbohydrates; in Mexico corn intake is the main energy source, and vitamins such as retinol and vitamin D were shown to be associated with this neoplasm in a protective way; nevertheless, further studies are necessary to allow us to corroborate the results.
A case-control study of diet and the risk of ovarian cancer.
  • S. Pan, A. Ugnat, Y. Mao, S. Wen, Kenneth C Johnson
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2004
TLDR
Ov ovarian cancer risk was positively associated with higher consumption of dietary cholesterol and eggs and inversely associated withHigher intake of total vegetables and cruciferous vegetables and supplementation of vitamin E, beta-carotene, and B-complex vitamins.
A prospective study of dietary lactose and ovarian cancer
TLDR
The findings provide some support for the hypothesis that lactose intake increases risk of epithelial ovarian cancer, and the observed excess risk appeared limited to the serous subtype of ovarian cancer in the study.
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Dietary factors in the etiology of ovarian cancer were investigated with the use of data from a case-control study conducted in Northern Italy on 455 histologically confirmed epithelial carcinomas
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TLDR
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Dietary Animal Fat in Relation to Ovarian Cancer Risk
TLDR
Dietary factors may partially explain variation in the international incidence of this disease and suggest a new pathway for its etiology.
Lactase persistence and milk consumption as determinants of ovarian cancer risk.
  • D. Cramer
  • Biology, Medicine
    American journal of epidemiology
  • 1989
TLDR
The author speculates that toxicity from the lactose component of milk and, more specifically, galactose, the digestion of which is facilitated by lactase persistence, may provide a biologic basis for the correlation.
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Galactose metabolism, hereditary defects and their clinical significance
Most galactose in the diet is in the form of the disaccharide lactose, which is synthesized in the mammary gland, mainly from glucose. Lactose is the primary carbohydrate source for nursing mammals
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TLDR
Entrapment of surface epithelium within the ovarian stroma was proposed as an initial event in the pathogenesis of cystadenocarcinoma of the ovary and animal experiments suggested that gonadotropin excess and stromal stimulation may result by disturbing normal feedback inhibition between ovarian and pituitary or by destroying ovarian follicles.
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TLDR
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