GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function.

@article{Lou2002GAIPGA,
  title={GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function.},
  author={Xiaojing Lou and Tammie J. McQuistan and Robert A. Orlando and Marilyn Gist Farquhar},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 4},
  pages={918-27}
}
Megalin is the most abundant endocytic receptor in the proximal tubule epithelium (PTE), where it is concentrated in clathrin-coated pits (CCPs) and vesicles in the brush border region. The heterotrimeric G protein alpha subunit, Galphai3, has also been localized to the brush border region of PTE. By immunofluorescence GIPC and GAIP, components of G protein… CONTINUE READING